Interactions between Teladorsagia circumcincta Infections and Microbial Composition of Sheep with or without Successful Monepantel Treatment—A Preliminary Study

Nematodes are one of the main impactors on health, welfare and productivity farmed animals. Teladorsagia circumcincta endemic throughout many sheep-producing countries, particularly in northern hemisphere, contribute to pathology economic losses seen farms. Control these nematode infections is essential heavily reliant chemotherapy (anthelmintics), but this has been compromised by development anthelmintic resistance. In mammals, composition intestinal microbiota shown have a significant effect overall health. The interactions between host, pathogens complex influenced numerous factors. study, comparisons faecal sheep infected with sensitive or resistant strains T. circumcincta, without monepantel administration were assessed. findings from both samples terminal ileum mucosal scrapings showed clear differences successfully treated animals those that left untreated and/or carrying nematodes. Specifically, potentially beneficial genus Bifidobacterium was identified as elevated detection other biomarkers will provide basis for new therapeutic reagents relevant problems emerging multidrug